Craniosynostosis, maxillary hyperplasia, delayed tooth eruption Supernumerary Teeth One Gene In Background
Researchers described a new recessively inherited human syndrome featuring craniosynostosis, maxillary hyperplasia, delayed tooth eruption and extra teeth. They also identified causative mutations in a gene IL11RA.
In craniosynostosis, the sutures between skull bones become ossified prematurely, affecting skull shape and limiting space for the growth of the brain. It is observed in 1:2500 and often requires operative surgery. Supernumerary teeth are more common, and in most cases they also require dental surgery.